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- Title
ANTI-VIRAL ACTIVITY OF Phyllanthus niruri AGAINST HEPATITIS C VIRUS.
- Authors
TUTIK SRI WAHYUNI; DZUL AZMI; ADITA AYU PERMANASARI; MYRNA ADIANTI; LYDIA TUMEWU; TRI WIDIANDANI; CHIE AOKI UTSUBO; ATY WIDYAWARUYANTI; ACHMAD FUAD; HAK HOTTA
- Abstract
Hepatitis C virus (HCV) infection is a global problem that causes liver disease and hepatocellular carcinoma. Although the current standard treatment provided a significant improvement on response rate with sustain virology response more than 90%, however, the high cost was remaining limited access to this therapy, resistance emergence and serious side effects which provide the necessities to find the new anti-HCV agents. The current study, we evaluated the ethanol extract of Phyllanthus niruri for its anti-HCV activities. Anti-HCV activity was determined by in vitro culture cells of Huh 7it. Anti-HCV activity of P. niruri extract revealed strong inhibition against HCV with IC50 values of 4.14 μg/mL and yield stronger activity in the entry step of the HCV life cycle. Moreover, the P. niruri extract enhanced anti-HCV activity of simeprevir (NS3 protease inhibitor) with increase the activity up to 4-fold compared to a single treatment of simeprevir. Docking analysis was performed to predict the interaction phyllanthin and hypophyllantin, known compounds of P. niruri against HCV receptor. Both of phyllantin and hypophyllantin were mediated a strong interaction with 4GAG, a protein that involved in entry step of HCV. These results suggested that the ethanol extract of P. niruri may be good candidates for the development of anti-HCV drugs.
- Subjects
HEPATITIS C virus; DRUG side effects; PHYLLANTHUS; CELL culture; THERAPEUTICS
- Publication
Malaysian Applied Biology, 2019, Vol 48, Issue 3, p105
- ISSN
0126-8643
- Publication type
Article