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- Title
The three pyridazines, three naphthyridines and two azoles: effect of the position of the second heteroatom on pK<sub>aH</sub> of their eight conjugate acids.
- Authors
Rachuru, Sanjeev; Padmavathi, Devarakonda A.; Ramavath, Ravi; Vandanapu, Jagannadham; Skelton, Adam A.
- Abstract
In the present work, how the position of the second nitrogen in the conjugate acids of the three pyridazines viz., 1,2-pyridazine, 1,3-pyridazine (the pyrimidine) and 1,4-pyridazine (the pyrazine) and three naphthyridines viz., cinnoline, quinazoline and quinoxaline changes the pKaH systematically is taken up. They decrease nearly by a factor of half each time in the class of their own. In contrast there is an increase in the pKaH when we move from pyrazole to imidazole. The pKaH of pyrazole is less than imidazole by −4.45 units. Suitable explanations are given.
- Subjects
NAPHTHYRIDINES; AZOLES; QUINAZOLINE; QUINOXALINES; PYRAZINES; PYRIMIDINES; PYRIDAZINES
- Publication
Zeitschrift für Physikalische Chemie, 2022, Vol 236, Issue 11/12, p1617
- ISSN
0942-9352
- Publication type
Article
- DOI
10.1515/zpch-2022-0111