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- Title
Case Report: Primary Breast Diffuses Large B-cell Lymphoma.
- Authors
Betty; Siregar, Denny Rifsal; Chrestela, Jessi; Laksmi, Lidya Imelda; Wahyuni, Sri
- Abstract
Introduction: Primary breast lymphoma (PBL) is a non-Hodgkin lymphoma (NHL) neoplasm that occurs very rarely in the breast, less than 1-2% of all NHL and less than 0.5% of all malignant neoplasms of the breast. PBL is defined as lymphoma confined to one or both breasts and/or regional lymph nodes, without a previous history of lymphoma. B-cell type breast lymphoma is more common than T-cell. About half of PBL are DLBCL. Case Description: A woman, MS, 41 years old with complaints of a lump in her right breast came for treatment to Medan City Hospital and underwent a mastectomy on her right breast. Then tissue was examined at the Anatomic Pathology Laboratory. Macroscopic examination, on cutting lamellar a tumor mass appears grayish white and brownish red, rubbery consistency that has circumscribed non-capsulated. Microscopic examination shows a tumor mass dominated by a diffuse distribution of relatively monotonous, medium-large sized atypical and pleomorphic cells (3-5 times size of mature lymphocyte cells) that resemble centroblast and immunoblast cells. Nuclei are round, ovoid, angulated, N/C ratio is increased, chromatin is rough with prominent nuclei, some are densely basophilic, cytoplasm eosinophilic. High atypical mitotic rate. Immunohistochemical examination negative for ER, PR, Her2 and CD3, positive for CD45 and CD20, high proliferation index Ki67 (>30%). Conclusion: Based on microscopic and immunohistochemical examination, this case was concluded to be a primary breast diffuse large B cell lymphoma (DLBCL), stage pT3N1Mx, ICD-O code: 9680/3.
- Subjects
DIFFUSE large B-cell lymphomas; B cell lymphoma; NON-Hodgkin's lymphoma; BREAST tumors
- Publication
Malaysian Journal of Medicine & Health Sciences, 2024, Vol 20, p98
- ISSN
1675-8544
- Publication type
Case Study