We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Enrichment of antibiotic resistance genes within bacteriophage populations in saliva samples from individuals undergoing oral antibiotic treatments.
- Authors
Andersson, Tilde; Makenga, Geofrey; Francis, Filbert; Minja, Daniel T. R.; Overballe-Petersen, Soren; Man-Hung Eric Tang; Fuursted, Kurt; Baraka, Vito; Lood, Rolf
- Abstract
Spread of antibiotic resistance is a significant challenge for our modern health care system, and even more so in developing countries with higher prevalence of both infections and resistant bacteria. Faulty usage of antibiotics has been pinpointed as a driving factor in spread of resistant bacteria through selective pressure. However, horizontal gene transfer mediated through bacteriophages may also play an important role in this spread. In a cohort of Tanzanian patients suffering from bacterial infections, we demonstrate significant differences in the oral microbial diversity between infected and non-infected individuals, as well as before and after oral antibiotics treatment. Further, the resistome carried both by bacteria and bacteriophages vary significantly, with blaCTX-M1 resistance genes being mobilized and enriched within phage populations. This may impact how we consider spread of resistance in a biological context, as well in terms of treatment regimes.
- Subjects
BACTERIOPHAGES; DRUG resistance in bacteria; ORAL drug administration; HORIZONTAL gene transfer; SALIVA; MICROBIAL diversity
- Publication
Frontiers in Microbiology, 2022, Vol 13, p1
- ISSN
1664-302X
- Publication type
Article
- DOI
10.3389/fmicb.2022.1049110