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- Title
Cord blood leptin level and a common variant of its receptor as determinants of the BMI trajectory: The EDEN mother–child cohort.
- Authors
Cissé, Aminata H.; Taine, Marion; Tafflet, Muriel; de Lauzon‐Guillain, Blandine; Clément, Karine; Khalfallah, Olfa; Davidovic, Laetitia; Lioret, Sandrine; Charles, Marie A.; Heude, Barbara
- Abstract
Summary: Background: Cord blood leptin is an indicator of neonatal fat mass and could shape postnatal adiposity trajectories. Investigating genetic polymorphisms of the leptin receptor gene (LEPR) could help understand the mechanisms involved. Objectives: We aimed to investigate the association of cord blood leptin level and the LEPR rs9436303 polymorphism, with body mass index (BMI) at adiposity peak (AP) and age at adiposity rebound (AR). Methods: In the EDEN cohort, BMI at AP and age at AR were estimated with polynomial mixed models, for 1713 and 1415 children, respectively. Multivariable linear regression models allowed for examining the associations of cord blood leptin level and LEPR rs9436303 genotype with BMI at AP and age at AR adjusted for potential confounders including birth size groups. We also tested interactions between cord blood leptin level and rs9436303 genotype. Results: Increased leptin level was associated with reduced BMI at AP and early age at AR (comparing the highest quintile of leptin level to the others). Rs9436303 G‐allele carriage was associated with increased BMI at AP and later age at AR but did not modulate the association with leptin level. Conclusion: These results illustrate the role of early life body composition and the intrauterine environment in the programming of adiposity in childhood.
- Subjects
FRANCE; BODY composition; ACADEMIC medical centers; LEPTIN; CHILD development; GENETIC polymorphisms; REGRESSION analysis; CORD blood; GENOTYPES; RESEARCH funding; BODY mass index; LONGITUDINAL method; ADIPOSE tissues; FETUS
- Publication
Pediatric Obesity, 2022, Vol 17, Issue 11, p1
- ISSN
2047-6302
- Publication type
Article
- DOI
10.1111/ijpo.12955