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- Title
The identity of the transcription +1 position is crucial for changes in gene expression in response to amino acid starvation in Bacillus subtilis.
- Authors
Krásný, Libor; Tišerová, Hana; Jonák, Jir¡í; Rejman, Dominik; Šanderová, Hana
- Abstract
We identify here a pattern in the transcription start sites (+1A or +1G) of σA-dependent promoters of genes that are up-/downregulated in response to amino acid starvation (stringent response) in Bacillus subtilis. Upregulated promoters initiate mostly with ATP and downregulated promoters with GTP. These promoters appear to be sensitive to changes in initiating nucleoside triphosphate concentrations. During the stringent response in B. subtilis, when ATP and GTP levels change reciprocally, the identity of the +1 position (A or G) of these promoters is a factor important in their regulation. Mutations that change the identity of position +1 (A for G and vice versa) change the response of the promoter to amino acid starvation.
- Subjects
GENETIC transcription; GENE expression; AMINO acids; BACILLUS subtilis; NUCLEOSIDES; GENETIC mutation
- Publication
Molecular Microbiology, 2008, Vol 69, Issue 1, p42
- ISSN
0950-382X
- Publication type
Article
- DOI
10.1111/j.1365-2958.2008.06256.x