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- Title
Memory Generation and Re-Activation in Food Allergy.
- Authors
Koenig, Joshua FE; Bruton, Kelly; Phelps, Allyssa; Grydziuszko, Emily; Jiménez-Saiz, Rodrigo; Jordana, Manel
- Abstract
Recent evidence has highlighted the critical role of memory cells in maintaining lifelong food allergies, thereby identifying these cells as therapeutic targets. IgG+ memory B cells replenish pools of IgE-secreting cells upon allergen exposure, which contract thereafter due to the short lifespan of tightly regulated IgE-expressing cells. Advances in the detection and highly dimensional analysis of allergen-specific B and T cells from allergic patients have provided insight on their phenotype and function. The newly identified Th2A and Tfh13 populations represent a leap in our understanding of allergen-specific T cell phenotypes, although how these populations contribute to IgE memory responses remains poorly understood. Within, we discuss the mechanisms by which memory B and T cells are activated, integrating knowledge from human systems and fundamental research. We then focus on memory reactivation, specifically, on the pathways of secondary IgE responses. Throughout, we identify areas of future research which will help identify immunotargets for a transformative therapy for food allergy.
- Subjects
FOOD allergy; DRUG target; T cells; B cells; DIMENSIONAL analysis
- Publication
ImmunoTargets & Therapy, 2021, Vol 10, p171
- ISSN
2253-1556
- Publication type
Article
- DOI
10.2147/ITT.S284823