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- Title
“In-Group” Communication in Marine <italic>Vibrio</italic>: A Review of N-Acyl Homoserine Lactones-Driven Quorum Sensing.
- Authors
Liu, Jianfei; Fu, Kaifei; Wu, Chenglin; Qin, Kewei; Li, Fei; Zhou, Lijun
- Abstract
N-Acyl Homoserine Lactones (N-AHLs) are an important group of small quorum-sensing molecules generated and released into the surroundings by Gram-negative bacteria. N-AHLs play a crucial role in various infection-related biological processes of marine <italic>Vibrio</italic> species, including survival, colonization, invasion, and pathogenesis. With the increasing problem of antibiotic abuse and subsequently the emergence of drug-resistant bacteria, studies on AHLs are therefore expected to bring potential new breakthroughs for the prevention and treatment of <italic>Vibrio</italic> infections. This article starts from AHLs generation in marine <italic>Vibrio</italic>, and then discusses the advantages, disadvantages, and trends in the future development of various detection methods for AHLs characterization. In addition to a detailed classification of the various marine <italic>Vibrio</italic>-derived AHL types that have been reported over the years, the regulatory mechanisms of AHLs and their roles in marine <italic>Vibrio</italic> biofilms, pathogenicity and interaction with host cells are also highlighted. Intervention measures for AHLs in different stages are systematically reviewed, and the prospects of their future development and application are examined.
- Subjects
VIBRIO; N-acyl-L-homoserine lactone; MICROBIAL virulence; QUORUM sensing; BIOLOGICAL invasions
- Publication
Frontiers in Cellular & Infection Microbiology, 2018, Vol 8, pN.PAG
- ISSN
2235-2988
- Publication type
Article
- DOI
10.3389/fcimb.2018.00139