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- Title
Catalpa bignonioides extract improves exercise performance through regulation of growth and metabolism in skeletal muscles.
- Authors
Jeong, Hoibin; Lee, Dong-joo; Kwon, Sung-Pil; Park, SeonJu; Kim, Song-Rae; Kim, Seung; Park, Jae-Il; Lee, Deug-chan; Choi, Kyung-Min; Lee, WonWoo; Park, Ji-Won; Yun, Bohyun; Cho, Su-Hyeon; Kim, Kil-Nam
- Abstract
Objective: To evaluate the effects of Catalpa bignonioides fruit extract on the promotion of muscle growth and muscular capacity in vitro and in vivo. Methods: Cell viability was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Cell proliferation was assessed using a 5-bromo-2'-deoxyuridine (BrdU) assay kit. Western blot analysis was performed to determine the protein expressions of related factors. The effects of Catalpa bignonioides extract were investigated in mice using the treadmill exhaustion test and whole-limb grip strength assay. Chemical composition analysis was performed using high-performance liquid chromatography (HPLC). Results: Catalpa bignonioides extract increased the proliferation of C2C12 mouse myoblasts by activating the Akt/mTOR signaling pathway. It also induced metabolic changes, increasing the number of mitochondria and glucose metabolism by phosphorylating adenosine monophosphate-activated protein kinase. In an in vivo study, the extract-treated mice showed improved motor abilities, such as muscular endurance and grip strength. Additionally, HPLC analysis showed that vanillic acid may be the main component of the Catalpa bignonioides extract that enhanced muscle strength. Conclusions: Catalpa bignonioides improves exercise performance through regulation of growth and metabolism in skeletal muscles, suggesting its potential as an effective natural agent for improving muscular strength.
- Subjects
METABOLIC regulation; REGULATION of growth; SKELETAL muscle; MUSCLE metabolism; EPICATECHIN; MUSCLE strength; DYNAMOMETER
- Publication
Asian Pacific Journal of Tropical Biomedicine, 2024, Vol 14, Issue 2, p47
- ISSN
2221-1691
- Publication type
Article
- DOI
10.4103/apjtb.apjtb_779_23