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- Title
Renoprotective effect of umbelliferone in high-fat diet/streptozotocin-induced type 2 diabetic rats.
- Authors
Naowaboot, Jarinyaporn; Somparn, Nuntiya; Saenthaweesuk, Suphaket
- Abstract
Objective: To evaluate the renoprotective effect of umbelliferone in high-fat diet/streptozotocin-induced type 2 diabetic rats. Methods: We established a streptozotocin-induced type 2 diabetic model in male Wistar rats. The rats were fed with high-fat diet (45 kcal% lard fat) and injected with 35 mg/kg streptozotocin. Diabetic rats were treated with umbelliferone for 8 weeks. At the end of the experimental period, the serum and kidney were used for measuring biochemical parameters, protein expression and histological analysis. Results: After 8-week treatment, umbelliferone decreased fasting plasma glucose, concentrations of malondialdehyde and monocyte chemoattractant protein-1 in the plasma and tissues. It also significantly reduced serum creatinine, blood urea nitrogen, serum advanced glycation end products, as well as kidney weight in type 2 diabetic rats (P<0.05). Moreover, umbelliferone reduced the 24-h urine albumin, but increased 24-h urine creatinine excretion (P<0.05). In renal protein expression, umbelliferone decreased the levels of transforming growth factor-ß1 and fibronectin while increasing the levels of superoxide dismutase and catalase (P<0.05). Renal histological examination revealed an enlarged glomerular size in diabetic rats, which was smaller in umbelliferone-treated diabetic rats. Conclusions: Umbelliferone alleviates renal dysfunction in diabetes via decreasing hyperglycemia, oxidative stress, inflammation and glycation.
- Subjects
BLOOD urea nitrogen; RATS; FIBRONECTINS; HIGH-fat diet; SUPEROXIDE dismutase; PROTEIN expression; URINE proteins
- Publication
Asian Pacific Journal of Tropical Biomedicine, 2020, Vol 10, Issue 1, p11
- ISSN
2221-1691
- Publication type
Article
- DOI
10.4103/2221-1691.273089