We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Tumor immune microenvironment of self-identified African American and non-African American triple negative breast cancer.
- Authors
Marczyk, Michal; Qing, Tao; O'Meara, Tess; Yagahoobi, Vesal; Pelekanou, Vasiliki; Bai, Yalai; Reisenbichler, Emily; Cole, Kimberly S.; Li, Xiaotong; Gunasekharan, Vignesh; Ibrahim, Eiman; Fanucci, Kristina; Wei, Wei; Rimm, David L.; Pusztai, Lajos; Blenman, Kim R. M.
- Abstract
Differences in the tumor immune microenvironment may result in differences in prognosis and response to treatment in cancer patients. We hypothesized that differences in the tumor immune microenvironment may exist between African American (AA) and NonAA patients, due to ancestry-related or socioeconomic factors, that may partially explain differences in clinical outcomes. We analyzed clinically matched triple-negative breast cancer (TNBC) tissues from self-identified AA and NonAA patients and found that stromal TILs, PD-L1 IHC-positivity, mRNA expression of immune-related pathways, and immunotherapy response predictive signatures were significantly higher in AA samples (p < 0.05; Fisher's Exact Test, Mann–Whitney Test, Permutation Test). Cancer biology and metabolism pathways, TAM-M2, and Immune Exclusion were significantly higher in NonAA samples (p < 0.05; Permutation Test, Mann–Whitney Test). There were no differences in somatic tumor mutation burden. Overall, there is greater immune infiltration and inflammation in AA TNBC and these differences may impact response to immune checkpoint inhibitors and other therapeutic agents that modulate the immune microenvironment.
- Subjects
TRIPLE-negative breast cancer; TUMOR microenvironment; AFRICAN Americans; EXPERIMENTAL arthritis; IMMUNE checkpoint inhibitors; FISHER exact test
- Publication
NPJ Breast Cancer, 2022, Vol 8, Issue 1, p1
- ISSN
2374-4677
- Publication type
Article
- DOI
10.1038/s41523-022-00449-3