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- Title
Cuantificación de niveles de INF-γ - IL-13 y células T CD4+, CD8+ en pacientes con leishmaniasis tegumentaria con falla terapéutica.
- Authors
León, Amilcar Flores; Cabrera, Ernesto Rojas; Rojas, Marisol Córdova; Torrico, Mary Cruz; Paz, David
- Abstract
Objectives: is a study of the immune status, quantifying the Th1 cytokine profile (IFN-γ) and Th2 (IL-13) and CD3 + T cells, CD4 + and CD8 + as variables that can provide information on the link and / or association therapeutic failure. Methods: we quantified the levels of INF-γ, IL-13, CD4 + and CD8 + in three study groups: a) patients with LT and therapeutic failure (RESISTANT), b) Treated patients who responded to treatment successfully (SENSITIVE ) c) healthy patients (CONTROL GROUP). Results: the results indicate that the specific immune response of resistant and sensitive patients is polarized toward the TH1 response and values of CD4 + T lymphocytes and CD8 + were below normal values in the three groups. The levels of IFN-γ production was higher than IL-13, being more pronounced in patients resistant to sensitive in response to Leishmania Ag, the typing of the strains that were isolated from patients resistant identified: Leishmania brasiliensis and guayanensis Leishmania. Conclusions: regarding treatment failure resistant patients, would also be involved factors related to the parasite and other extrinsic factors to the host.
- Subjects
T cells; LEISHMANIASIS; CYTOKINES; DISEASE relapse; IMMUNE response; INTERFERONS
- Publication
Gaceta Médica Boliviana, 2013, Vol 36, Issue 1, p15
- ISSN
1012-2966
- Publication type
Article