We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Efficacy of different concentrations of ciclopirox shampoo for the treatment of seborrheic dermatitis of the scalp: Results of a randomized, double-blind, vehicle-controlled trial.
- Authors
Altmeyer, Peter; Hoffmann, Klaus
- Abstract
Seborrheic dermatitis is a common inflammatory skin disorder affecting 1–3% of the population. It is thought to be linked to dandruff via a common etiology, yeasts of the genus Malassezia. Ciclopirox is a broad-spectrum, hydroxypyridone-derived, synthetic antifungal agent with anti-inflammatory properties. A total of 203 patients were enrolled in this vehicle-controlled, double-blind, randomized study designed to compare vehicle with three different concentrations of ciclopirox shampoo: 0.1%, 0.3% and 1%, with each applied twice a week. The main efficacy parameters were based on 6-point ordinal scales describing the disease's signs and symptoms (scaling, inflammation and itching), global status of disease, and global change in disease. A tendency towards improvement of the sum score from baseline was found in all ciclopirox treatment groups. The most pronounced improvement was found in the ciclopirox 1% group, which changed from a baseline sum score of 8.3 to 4.4 at the end of the 4-week study period ( P-value vs. vehicle 0.0372). In addition, the therapeutic index showed increasing efficacy with the use of increased concentrations of ciclopirox. The study supports the use of 1% ciclopirox shampoo in the treatment of seborrheic dermatitis of the scalp. Furthermore, ciclopirox shampoo at each concentration was found to be safe and well tolerated.
- Subjects
DISEASES; SCALP; SKIN inflammation; ANTI-inflammatory agents; ITCHING; SHAMPOOS; CICLOPIROX; PREVENTION
- Publication
International Journal of Dermatology, 2004, Vol 43, p9
- ISSN
0011-9059
- Publication type
Article
- DOI
10.1111/j.1461-1244.2004.02381.x