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- Title
MicroRNA-101 is upregulated in human diabetic nephropathy.
- Authors
Siddiqi, Ferhan S.; Majumdar, S.; Advani, A.; Geldenhuys, L.
- Abstract
The pathogenesis of oxidative stress and renal dysfunction in diabetic nephropathy has recently been shown to be under epigenetic control. A paired system involving the histone methyltransferase EZH2 and its regulatory microRNA, miR-101, influence oxidative injury and proteinuria in cell culture and animal models of diabetic nephropathy. This study aimed to identify dysregulation of EZH2 and miR-101 expression in human diabetic nephropathy. Archived kidney tissue samples from nephrectomy for renal cell carcinoma were selected from patients with diabetic nephropathy and matched controls. By RTQ-PCR, the expression of EZH2 in renal cortical samples showed no difference between groups (p=NS). However, miR-101 expression was upregulated in patients with diabetic nephropathy as compared to controls (p<0.05). This represents a novel finding implying that differences in epigenetic regulation may lead to the development and progression of nephropathy in patients with diabetes.
- Publication
Canadian Journal of Pathology, 2016, Vol 8, p35
- ISSN
1918-915X
- Publication type
Article