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- Title
Emerging Roles for the Gut Microbiome in Lymphoid Neoplasms.
- Authors
Shi, Zhuangzhuang; Zhang, Mingzhi
- Abstract
Lymphoid neoplasms encompass a heterogeneous group of malignancies with a predilection for immunocompromised individuals, and the disease burden of lymphoid neoplasms has been rising globally over the last decade. At the same time, mounting studies delineated a crucial role of the gut microbiome in the aetiopathogenesis of various diseases. Orchestrated interactions between myriad microorganisms and the gastrointestinal mucosa establish a defensive barrier for a range of physiological processes, especially immunity and metabolism. These findings provide new perspectives to harness our knowledge of the gut microbiota for preclinical and clinical studies of lymphoma. Here, we review recent findings that support a role for the gut microbiota in the development of lymphoid neoplasms and pinpoint relevant molecular mechanisms. Accordingly, we propose the microbiota-gut-lymphoma axis as a promising target for clinical translation, including auxiliary diagnosis, novel prevention and treatment strategies, and predicting clinical outcomes and treatment-related adverse effects of the disease in the future. This review will reveal a fascinating avenue of research in the microbiota-mediated lymphoma field.
- Subjects
INTESTINAL mucosa physiology; LYMPHOMA risk factors; GUT microbiome; MOLECULAR biology; TREATMENT effectiveness; IMMUNITY; ADVERSE health care events
- Publication
Clinical Medicine Insights: Oncology, 2021, p1
- ISSN
1179-5549
- Publication type
Article
- DOI
10.1177/11795549211024197