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- Title
Vitamin D levels predict the response to cardiac resynchronization therapy in patients with systolic heart failure.
- Authors
Sunman, Hamza; Özkan, Adem; Yorgun, Hikmet; Canpolat, Uğur; Maharjan, Naresh; Asil, Serkan; Kaya, Ergün Barış; Bayrak, Tülin; Tokgözoğlu, Lale; Özkara, Asuman; Aytemir, Kudret; Oto, Ali
- Abstract
Objective: The aim of this study was to examine the relationship between vitamin D levels in patients with heart failure (HF) and response to cardiac resynchronization therapy (CRT). Methods: We studied 57 patients (mean age: 60.47±13.09 years) with New York Heart Association Class II or III heart failure, QRS duration =120 milliseconds, and ejection fraction <35% (mean: 27.1±4.4%) who underwent CRT. All patients were taking optimal medical treatment for HF. Patients were classified as CRT responders if they had >15% decrease in left ventricular end-systolic volume at 6 months compared with baseline measurements. Vitamin D levels were evaluated before CRT implantation with ELISA. Results: Of the 57 patients, 34 patients (59.6%) were classified as responders and 23 patients (40.4%) were classified as non-responders. Baseline features, laboratory findings, and echocardiographic characteristics were nearly the same in both groups. High vitamin D level was detected in responder group compared to non-responder group (26.17±7.5 vs 21.15±5.9; p=0.009). Age, hypertension, diabetes mellitus, ischemic cardiomyopathy, QRS morphology and duration, and levels of B-type natriuretic peptide (BNP) and vitamin D were associated with CRT response in our study population. In multivariate regression analysis, preimplantation QRS duration, and BNP and vitamin D levels remained independent predictors (QRS duration Odds ratio [OR]: 1.047, CI: 1.019-1.417, p=0.006; BNP OR: 0.997, 95% CI: 0.994-0.999, p=0.029; vitamin D OR: 1.121, 95% CI: 1.011-1.242, p=0.030). Conclusion: In the present study, preimplantation level of vitamin D was found to be predictor of response to CRT, independent of BNP.
- Publication
Archives of the Turkish Society of Cardiology / Türk Kardiyoloji Derneği Arşivi, 2016, Vol 44, Issue 8, p670
- ISSN
1016-5169
- Publication type
Article
- DOI
10.5543/tkda.2016.28848