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- Title
Genome-wide association of major depression: description of samples for the GAIN Major Depressive Disorder Study: NTR and NESDA biobank projects.
- Authors
Boomsma, Dorret I.; Willemsen, Gonneke; Sullivan, Patrick F.; Heutink, Peter; Meijer, Piet; Sondervan, David; Kluft, Cornelis; Smit, Guus; Nolen, Willem A.; Zitman, Frans G.; Smit, Johannes H.; Hoogendijk, Witte J.; Van Dyck, Richard; De Geus, Eco J. C.; Penninx, Brenda W. J. H.
- Abstract
To identify the genomic regions that confer risk and protection for major depressive disorder (MDD) in humans, large-scale studies are needed. Such studies should collect multiple phenotypes, DNA, and ideally, biological material that allows gene expression analysis, transcriptomic, proteomic, and metabolomic studies. In this paper, we briefly review linkage studies of MDD and then describe the large-scale nationwide biological sample collection in Dutch twin families from the Netherlands Twin Register (NTR) and in participants in the Netherlands Study of Depression and Anxiety (NESDA). Within these studies, 1862 participants with a diagnosis of MDD and 1857 controls at low liability for MDD have been selected for genome-wide genotyping by the US Foundation for the National Institutes of Health Genetic Association Information Network. Stage 1 genome-wide association results are scheduled to be accessible before the end of 2007. Genome-wide association results are open-access and can be viewed at the dbGAP web portal (http://www.ncbi.nlm.nih.gov). Approved users can download the genotype and phenotype data, which have been made available as of 9 October 2007.European Journal of Human Genetics (2008) 16, 335–342; doi:10.1038/sj.ejhg.5201979; published online 16 January 2008
- Subjects
MENTAL depression; PHENOTYPES; DEPRESSED persons; HUMAN genetics; GENOMICS; DNA
- Publication
European Journal of Human Genetics, 2008, Vol 16, Issue 3, p335
- ISSN
1018-4813
- Publication type
Article
- DOI
10.1038/sj.ejhg.5201979