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- Title
Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway.
- Authors
Ki-Jun Yoon; Hye-Ryeon Lee; Yong Sang Jo; Kyongman An; Sang-Yong Jung; Min-Woo Jeong; Seok-Kyu Kwon; Nam-Shik Kim; Hyun-Woo Jeong; Seo-Hee Ahn; Kyong-Tai Kim; Kyungmin Lee; Eunjoon Kim; Joung-Hun Kim; June-Seek Choi; Bong-Kiun Kaang; Young-Yun Kong
- Abstract
Background: Notch signaling is well recognized as a key regulator of the neuronal fate during embryonic development, but its function in the adult brain is still largely unknown. Mind bomb-1 (Mib1) is an essential positive regulator in the Notch pathway, acting non-autonomously in the signal-sending cells. Therefore, genetic ablation of Mib1 in mature neuron would give valuable insight to understand the cell-to-cell interaction between neurons via Notch signaling for their proper function. Results: Here we show that the inactivation of Mib1 in mature neurons in forebrain results in impaired hippocampal dependent spatial memory and contextual fear memory. Consistently, hippocampal slices from Mib1-deficient mice show impaired late-phase, but not early-phase, long-term potentiation and long-term depression without change in basal synaptic transmission at SC-CA1 synapses. Conclusions: These data suggest that Mib1-mediated Notch signaling is essential for long-lasting synaptic plasticity and memory formation in the rodent hippocampus.
- Subjects
NOTCH genes; NEURAL circuitry; HIPPOCAMPUS (Brain); EMBRYOLOGY; MEMORY; NEURONS
- Publication
Molecular Brain, 2012, Vol 5, Issue 1, p40
- ISSN
1756-6606
- Publication type
Article
- DOI
10.1186/1756-6606-5-40