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- Title
Bilateral uveal melanomas with different gene expression detected with 7 years interval.
- Authors
Eide, Nils; Garred, Øystein; Beiske, Klaus; Fodstad, Øystein
- Abstract
Purpose To report a bilateral uveal melanoma detected in a micrometastasis study. Method Case report. Results At enucleation of a circumpapillary amelanotic mixed melanoma in a patient with ocular melanocytosis, a pigmented lesion in the other eye was detected, thought to be a naevus. BAP1 was positive showing nuclear staining of the tumour cells. Seven years later the naevus showed growth and development of a retinal detachment. FNAB disclosed monosomy 3 in the spindle tumour cells. Conclusion A case of bilateral melanoma with long-term survival without metastatic diseases is reported. Different gene expressions in the two eyes were revealed. The case is a reminder that follow-up over years is essential in patients with a uveal melanoma, especially with ocular melanocytosis.
- Subjects
UVEAL diseases; MELANOMA diagnosis; RETINAL detachment; RETINAL diseases; METASTASIS; THERAPEUTICS
- Publication
Acta Ophthalmologica (1755375X), 2016, Vol 94, Issue 1, p99
- ISSN
1755-375X
- Publication type
Article
- DOI
10.1111/aos.12857