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- Title
Behavioral and neurochemical profile of some novel phenacyl based isonipecotamide derivatives.
- Authors
Akhtar, Shamim; Arif, Muhammad; Mushtaq, Nousheen; Saify, Zafar Saeed; Ahmed, Ahsaan; Haleem, Darakhshan Jabeen; Akram, Arfa
- Abstract
Study of natural products led to the development of new molecules of potential biological activity. Piperidine nucleus constitutes one of the components of various alkaloids and drugs. During the course of our project regarding the synthesis of derivatives of piperidine carboxamide to study the effects of these compounds as anti-depressive agents, some of the compounds exhibited significant effects at all three doses, through open field activity thus establishing a direct relationship between dose and locomotion. Moreover, these compounds have also shown the decreased level of 5-HT alone with increased level of dopamine as an indication of their antagonism towards 5-HT receptor.
- Subjects
NEUROCHEMISTRY; THIOCARBAMATES; ANTIDEPRESSANTS; NATURAL products; PIPERIDINE; ALKALOIDS; CARBOXAMIDES
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2012, Vol 25, Issue 4, p705
- ISSN
1011-601X
- Publication type
Article