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- Title
Deciphering resistancemechanisms and novel strategies to overcome drug resistance in ovarian cancer: a comprehensive review.
- Authors
ALEMZADEH, EFFAT; ALLAHQOLI, LEILA; MAZIDIMORADI, AFROOZ; ALEMZADEH, ESMAT; GHASEMI, FAHIMEH; SALEHINIYA, HAMID; ALKATOUT, IBRAHIM
- Abstract
Ovarian cancer is among the most lethal gynecological cancers, primarily due to the lack of specific symptoms leading to an advanced-stage diagnosis and resistance to chemotherapy. Drug resistance (DR) poses the most significant challenge in treating patients with existing drugs. The Food and Drug Administration (FDA) has recently approved three new therapeutic drugs, including two poly (ADP-ribose) polymerase (PARP) inhibitors (olaparib and niraparib) and one vascular endothelial growth factor (VEGF) inhibitor (bevacizumab) for maintenance therapy. However, resistance to these new drugs has emerged. Therefore, understanding the mechanisms of DR and exploring new approaches to overcome them is crucial for effective management. In this review, we summarize the major molecular mechanisms of DR and discuss novel strategies to combat DR.
- Subjects
UNITED States. Food &; Drug Administration; DRUG resistance in cancer cells; VASCULAR endothelial growth factors; DRUG resistance; OVARIAN cancer; POLY(ADP-ribose) polymerase
- Publication
Oncology Research, 2024, Vol 32, Issue 5, p831
- ISSN
0965-0407
- Publication type
Article
- DOI
10.32604/or.2024.031006