We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effect of epicatechin on inflammatory cytokines and MAPK/NF-ΰB signaling pathway in lipopolysaccharide-induced acute lung injury of BALB/c mice.
- Authors
Zelin Li; Xiaoping Fu; Yingrun Fan; Chunyan Zhao; Qiuting Wang; Li Feng; Xiaojing Shen; Zhonghui Han; Jiangping Fan
- Abstract
This study evaluated the anti-inflammatory effect of epicatechin (EC) on acute lung injury (ALI) induced by lipopolysaccharide (LPS) of tracheal installation in BALB/c mice. It was observed that EC could alleviate not only the histopathological changes but also decrease the wet/dry weight (W/D) ratio of lung tissues. It also suppressed the release of IL-1β, IL-6, and TNF-α in serum, bronchoalveolar lavage fluid (BALF), and lung tissues, respectively. A quantitative realtime PCR-based study further indicated that EC also inhibited the levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA in lung tissues. In addition, the Western blot report suggested that EC was closely involved in the inhibition of phosphorylation of ERK, JNK, p38, p65, and IκB in mitogen-activated protein kinases (MAPK) and nuclear factor-κB (NF-κB) signaling pathway. These results provide an experimental and theoretical basis for treating pulmonary inflammation by EC.
- Subjects
LIPOPOLYSACCHARIDES; LUNG injuries; MITOGEN-activated protein kinases; EPICATECHIN; NITRIC-oxide synthases; CELLULAR signal transduction; PLANT polyphenols
- Publication
General Physiology & Biophysics, 2022, Vol 41, Issue 4, p299
- ISSN
0231-5882
- Publication type
Article
- DOI
10.4149/gpb_2022023