We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Low-Dose Fluconazole as Primary Prophylaxis for Cryptococcal Infection in AIDS Patients with CD4 Cell Counts of ≤100/mm3: Demonstration of Efficacy in a Prospective, Multicenter Trial.
- Authors
Singh, Nina; Barnish, Michael J.; Berman, Steven; Bender, Bradley S.; Wagener, Marilyn M.; Rinaldi, Michael G.; Yu, Victor L.
- Abstract
The efficacy of low-dose fluconazole (200 mg orally administered thrice weekly) as primary prophylaxis for cryptococcal infection was prospectively assessed in a multicenter trial involving 218 patients who were infected with human immunodeficiency virus (HIV) and who had CD4 cell counts of ≤100/mm3. The median CD4 cell count at baseline was 39/mm3; 58% of the patients had an AIDS-defining illness or infection prior to enrollment. Cryptococcal meningitis occurred in 0.4% (1) of the 218 patients. The breakthrough isolate was susceptible to fluconazole, and the fluconazole kinetic study demonstrated adequate drug absorption and serum fluconazole levels; noncompliance could not be excluded in this case. Mucocutaneous and/or esophageal candidiasis developed in 18% (40) of the patients. Noncompliance with fluconazole therapy was the only variable independently associated with breakthrough candidiasis in the study patients (P = .00002). Thus, fluconazole (200 mg thrice weekly) given to HIV-infected patients with CD4 cell counts of ≤100/mm3 was efficacious as primary prophylaxis for cryptococcosis, with notably lower costs and increased convenience for patients in comparison with daily administration of the drug.
- Publication
Clinical Infectious Diseases, 1996, Vol 23, Issue 6, p1282
- ISSN
1058-4838
- Publication type
Article