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- Title
An Electrophilic Reagent for the Direct Introduction of the SCF<sub>2</sub>PO(OEt)<sub>2</sub> Group to Molecules.
- Authors
Xiong, Heng‐Ying; Bayle, Alexandre; Pannecoucke, Xavier; Besset, Tatiana
- Abstract
An unprecedented electrophilic difluoromethylthiolating reagent (MesNHSCF2PO(OEt)2) was designed. Under mild and metal-free conditions, this new reagent reacted with various nucleophiles, thus offering an efficient and operationally simple tool for the construction of C−SCF2PO(OR)2, N−SCF2PO(OR)2, and S−SCF2PO(OR)2 bonds. Finally, thanks to this new methodology, the synthesis of the non-stereoidal anti-inflammatory diflumidone was achieved.
- Subjects
ELECTROPHILIC substitution reactions; SELF-consistent field theory; ELECTROPHILES; NUCLEOPHILIC addition (Chemistry); FUNCTIONAL groups
- Publication
Angewandte Chemie International Edition, 2016, Vol 55, Issue 43, p13490
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201607231