We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A [4+1] Cyclative Capture Approach to 3H-Indole-N-oxides at Room Temperature by Rhodium(III)-Catalyzed C-H Activation.
- Authors
Yang, Yaxi; Wang, Xuan; Li, Yuanchao; Zhou, Bing
- Abstract
The rhodium(III)-catalyzed [3+2] C-H cyclization of aniline derivatives and internal alkynes represents a useful contribution to straightforward synthesis of indoles. However, there is no report on the more challenging synthesis of pharmaceutically important N-hydroxyindoles and 3H-indole- N-oxides. Reported herein is the first rhodium(III)- catalyzed [4+1] C-H oxidative cyclization of nitrones with diazo compounds to access 3H-indole-N-oxides. More significantly, this reaction proceeds at room temperature and has been extended to the synthesis of N-hydroxyindoles and N-hydroxyindolines.
- Subjects
RHODIUM catalysts; PLATINUM group catalysts; ALKYNES; INDOLE compounds; RING formation (Chemistry)
- Publication
Angewandte Chemie International Edition, 2015, Vol 54, Issue 51, p15400
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201508702