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- Title
Direct Synthesis of 5-Aryl Barbituric Acids by Rhodium(II)-Catalyzed Reactions of Arenes with Diazo Compounds.
- Authors
Best, Daniel; Burns, David J.; Lam, Hon Wai
- Abstract
A commercially available rhodium(II) complex catalyzes the direct arylation of 5-diazobarbituric acids with arenes, allowing straightforward access to 5-aryl barbituric acids. Free NH groups are tolerated on the barbituric acid, with no complications arising from NH insertion processes. This method was applied to the concise synthesis of a potent matrix metalloproteinase (MMP) inhibitor.
- Subjects
MATRIX metalloproteinases; RHODIUM; AROMATIC compounds; DIAZO compounds; CHEMICAL synthesis
- Publication
Angewandte Chemie International Edition, 2015, Vol 54, Issue 25, p7410
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201502324