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- Title
Neuregulin 1-alpha regulates phosphorylation, acetylation, and alternative splicing in lymphoblastoid cells<sup>1</sup>.
- Authors
Ghahramani Seno, Mohammad M.; Gwadry, Fuad G.; Hu, Pingzhao; Scherer, Stephen W.; Naumova, Anna K.
- Abstract
Neuregulins (NRGs) are signaling molecules involved in various cellular and developmental processes. Abnormal expression and (or) genomic variations of some of these molecules, such as NRG1, have been associated with disease conditions such as cancer and schizophrenia. To gain a comprehensive molecular insight into possible pathways/networks regulated by NRG1-alpha, we performed a global expression profiling analysis on lymphoblastoid cell lines exposed to NRG1-alpha. Our data show that this signaling molecule mainly regulates coordinated expression of genes involved in three processes: phosphorylation, acetylation, and alternative splicing. These processes have fundamental roles in proper development and function of various tissues including the central nervous system (CNS)-a fact that may explain conditions associated with NRG1 dysregulations such as schizophrenia. The data also suggest NRG1-alpha regulates genes ( FBXO41) and miRNAs (miR-33) involved in cholesterol metabolism. Moreover, RPN2, a gene already shown to be dysregulated in breast cancer cells, is also differentially regulated by NRG1-alpha treatment.
- Subjects
NEUREGULINS; LATENT class analysis (Statistics); ETIOLOGY of cancer; ETIOLOGY of schizophrenia; LYMPHOBLASTOID cell lines; CENTRAL nervous system; CHOLESTEROL metabolism inhibitors; BREAST cancer treatment
- Publication
Genome, 2013, Vol 56, Issue 10, p619
- ISSN
0831-2796
- Publication type
Article
- DOI
10.1139/gen-2013-0068