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- Title
Hereditary angioedema in cardiac surgery: Perioperative management considerations for a rare disease.
- Authors
Adami, Enrica Chiara; Magri, Federica; Plotti, Chiara; Renzi, Stefania; Chiarini, Giovanni; De Cicco, Giuseppe
- Abstract
Introduction: Hereditary Angioedema is a rare disease caused by C1 esterase inhibitor deficiency leading to diffuse and potentially life-threatening oedema formation. Preventing attacks is critical, particularly for patients undergoing cardiac surgery. Case Report: We report a case of a 71-years-old woman with a history of Hereditary Angioedema scheduled for open-heart surgery on Cardiopulmonary Bypass. Multidisciplinar teamwork and patient-targeted strategy were crucial to obtain a favorable outcome. Discussion: Cardiac surgery is a major stressor for Angioedema attacks because of Complement cascade and inflammatory response activation leading to potential life-threatening oedema formation. In literature only few cases of complex open heart surgery under Cardiopulmonary Bypass are described. Conclusion: Continuous updating and multidisciplinarity are key elements to manage patients with Hereditary Angioedema in cardiac surgery in order to reduce morbidity and mortality.
- Subjects
TRANSESOPHAGEAL echocardiography; PULMONARY function tests; RARE diseases; CARDIOPULMONARY bypass; TREATMENT effectiveness; CHEST X rays; MITRAL valve insufficiency; ROUTINE diagnostic tests; GENETIC disorders; ANGIONEUROTIC edema; MEDICAL screening; CORONARY angiography; PERIOPERATIVE care; CARDIAC surgery; TRICUSPID valve diseases
- Publication
Perfusion, 2024, Vol 39, Issue 5, p1017
- ISSN
0267-6591
- Publication type
Article
- DOI
10.1177/02676591231174773