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- Title
Transition-Metal-Free Synthesis of N-Hydroxy Oxindoles by an Aza-Nazarov-Type Reaction Involving Azaoxyallyl Cations.
- Authors
Ji, Wenzhi; Liu, Yahu A.; Liao, Xuebin
- Abstract
A novel transition-metal-free method to construct N-hydroxy oxindoles by an aza-Nazarov-type reaction involving azaoxyallyl cation intermediates is described. A variety of functional groups were tolerated under the weak basic reaction conditions and at room temperature. A one-pot process was also developed to make the reaction even more practical. This method provides alternative access to oxindoles and their biologically active derivatives.
- Subjects
TRANSITION metal compounds synthesis; RING formation (Chemistry); OXINDOLES; FUNCTIONAL groups; CHEMICAL reactions; BIOACTIVE compounds
- Publication
Angewandte Chemie International Edition, 2016, Vol 55, Issue 42, p13286
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201607177