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- Title
Genoprotective effects of Zataria multilflora and Myrtus communis with ketoconazole in the COMET assay on human B-lymphocytes.
- Authors
Ayubi, Zeinab; Ayatollahi-Mousavi, Seyed Amin; jafari, Abbas Ali; panddeh, Masoud
- Abstract
Introduction: In the traditional systems of medicine, medicinal plants are important sources of safe chemical substances with potential therapeutic effects. In the recent years, tendency to herbal medicine has been increased and people have recognized and used of many cultivated or wild plants and its products have less toxic effects than synthetic drugs and are a good source for novel therapeutic agents. Zataria multilflora and Myrtus communis are known as two Iranian herbal medicines, which widely used for remedy of different disorders. In this study, we investigated the protective effect of hydro-alcoholic extracts of these plants against genotoxic induced by Ketoconazole using Comet assay. Materials and Methods: Human B lymphocytes were treated with 1% of Zataria multilflora, 0.5% of Myrtus communis hydro-alcoholic extracts and ketoconazole simultaneously for assessment of DNA damages of incubated B lymphocytes by using Comet assay. Result: Our results showed that these hydro-alcoholic extracts significantly prevented from DNA damage within 3 and 24 hours after incubation of B lymphocytes compare to ketoconazole control group after 24 hours. We observed a statistically significant in DNA damages in treated B lymphocytes with herbal extracts to compare with ketoconazole after 24 hours (P<0.05). Conclusion: Results of this study has shown that hydro-alcoholic extracts of Zataria multilflora, of Myrtus communis were not genotoxic agents but exhibited significant protective activity during use in leukocytes. However, further In vitro and in vivo research is necessary for evaluation of safety of these extracts.
- Subjects
IRAN; AGAR; B cells; CONFERENCES &; conventions; DNA; ELECTROPHORESIS; KETOCONAZOLE; PLANT extracts; PHARMACODYNAMICS
- Publication
Current Medical Mycology, 2018, Vol 4, p178
- ISSN
2423-3439
- Publication type
Article
- DOI
10.18502/cmm.4.S1.2018.180