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- Title
Sciatic nerve injury model in rabbits: What to expect.
- Authors
Farinas, Angel F; Stephanides, Michael; Kassis, Salam; Keller, Patrick; Colazo, Juan M.; Thayer, Wesley P.
- Abstract
Rabbits are commonly used for sciatic nerve injuries larger than 1.5 cm. This report provides insight into risks and benefits associated with using rabbit models in sciatic nerve injury models and proposes interventions that researchers can use to prevent experimental complications. Fifty-six rabbits from a sciatic nerve injury study that involved a 40 mm sciatic nerve injury were analyzed to examine postoperative complication rates. Autophagy of the phalanges and plantar pressure ulcer development were the most common and serious complications faced. These complications led to 23.2% (n = 13) of rabbits not being used for data in the original experiment due to euthanasia outside of intended postoperative time points. This increased the cost needed to complete the experiment by $25,038.44. It is our recommendation that alternative models be used instead of rabbits for sciatic nerve injuries. If rabbits must be used, a treatment protocol for preventing autophagy and pressure ulcers is outlined below.
- Subjects
SCIATIC nerve injuries; RABBITS; PRESSURE ulcers; MEDICAL protocols; AUTOPHAGY
- Publication
Laboratory Animals, 2020, Vol 54, Issue 6, p559
- ISSN
0023-6772
- Publication type
Article
- DOI
10.1177/0023677219898481