We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Antimigraine Effects of Awei Wu Wei Pills, A Monk's Medicine.
- Authors
Xiaorong Wang; Wenjing Hu; Tuya Wang; Gaowa Wuyun
- Abstract
The Mongolian medicine (Awei Wu Wei pills) was evaluated as a potential treatment for Hirschsprung's migraine in a Sprague-Dawley rat model. The results of this study showed a dose-dependent decrease in the duration of ear redness and head scratching, two behavioral attributes of migraine. The mechanism involves inhibition of the c-Jun N-terminal kinase signaling pathway, leading to decreased calcitonin gene-related peptide and nitric oxide expression and reducing vasodilation, serotonin, dopamine, and beta-endorphin concentrations following administration of Awei Wu Wei pills. In conclusion, Awei Wu Wei pills demonstrate promising antimigraine effects.
- Subjects
MONGOLIA; BIOLOGICAL models; MEDICINAL plants; MIGRAINE; ANIMAL experimentation; NEUROPEPTIDES; SEROTONIN; TRADITIONAL medicine; RATS; EAR; HEAD; CELLULAR signal transduction; VASODILATION; DOPAMINE; DOSE-effect relationship in pharmacology; RESEARCH funding; PLANT extracts; MITOGEN-activated protein kinases; NITRIC oxide; ENDORPHINS
- Publication
Current Topics in Nutraceutical Research, 2023, Vol 21, Issue 4, p516
- ISSN
1540-7535
- Publication type
Article
- DOI
10.37290/ctnr2641-452X.21:516-523