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- Title
Chronic lymphocytic leukemia. Immunologic markers and functional properties of the leukemic cells.
- Authors
Van Reijden, Hendrik J. Der; Van Der Gaag, Ruth; Pinkster, Jantina; Rümke, Hans C.; Van'T Veer, Mars B.; Melief, Cornelis J. M.; Von Demborne, Albert E. G. Kr.; van der Reijden, H J; van der Gaag, R; Pinkster, J; Rümke, H C; van't Veer, M B; Melief, C J; von dem Borne, A E
- Abstract
In 230 cases of chronic lymphocytic leukemia (CLL), marker analysis was performed with rosette techniques and a panel of xeno-antisera. A monoclonal B-cell proliferation was found in the majority of cases (94%). In most cases, the B-cells carried IgM, with or without IgD. Cytoplasmic immunoglobulin-inclusion bodies were seen in 7% of the cases of B-CLL. The number of patients with non-B/non-T-CLL was small (2%) in this series. In eight patients (4%), a proliferation of T-cells was established. These patients had a different clinical presentation and marker analysis of the lymphocytes, together with functional studies, showed that this group represented a mixture of different disease processes. Functional analysis of the B-CLL cells in 19 cases showed a poor or absent mitogen response and in nine cases the absence of the capacity to differentiate in vitro into plasma cells and/or to produce immunoglobulins.
- Publication
Cancer (0008543X), 1982, Vol 50, Issue 12, p2826
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19821215)50:12<2826::AID-CNCR2820501223>3.0.CO;2-F