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- Title
Primary leptomeningeal melanoma. Diagnosis by ultrastructural cytology of cerebrospinal fluid and cranial computed tomography.
- Authors
Aichner, Franz; Schuler, Gerold; Aichner, F; Schuler, G
- Abstract
A case of primary leptomeningeal melanoma is presented in which the diagnosis was made by ultrastructural demonstration of melanoma cells from the cerebrospinal fluid (CSF) at a time when cranial computed tomography (CT) still gave negative results. Later CT examinations documented the emergence of a tumor mass of the left temporoparietal lobe. This case clearly illustrates the complementary role of these investigational procedures for the diagnosis of cerebrospinal melanoma: leptomeningeal involvement, characterized by two-dimensional diffuse spread of melanoma tissue ("leptomeningeal melanomatosis"), is invisible with CT, but easily recognisable by CSF cytology; in contrast, nodular parenchymal tumor deposits can be readily detected by CT. Identification of pigmented cells recovered from the CSF requires ultrastructural confirmation.
- Publication
Cancer (0008543X), 1982, Vol 50, Issue 9, p1751
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19821101)50:9<1751::AID-CNCR2820500918>3.0.CO;2-Q