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- Title
Correlation of the Antiproliferative Effect and the Mx-Homologous Protein Induction by IFN in Patients with Malignant Melanoma.
- Authors
Jakschies, Detlef; Hochkeppel, Heinz-Kurt; Horisberger, Michel Andre; Deicher, Helmuth; Wussow, Peter Von
- Abstract
The human interferon-induced intracellular protein homologous to the murine Mx-protein has recently been identified by means of a specific monoclonal antibody. Three of six melanoma cell lines elicited this intracellular human Mx-homolog upon incubation with IFN-α or IFN-γ, yet all six melanoma cell lines tested were susceptible to the antiproliferative effect of IFN-α and IFN-&alpha. Compared per antiviral unit, IFN-γ had weaker Mx-inducing but stronger antiproliferative activity than IFN-α. These data suggest that the IFN-induced Mx-homologous protein is not involved in the antiproliferative action of IFN on malignant melanoma cell lines. Furthermore, 51 patients with advanced malignant melanoma were treated thrice weekly with 10 × 106 IU rIFN-α-2b and 6 × 106 nIFN-<α, respectively. Nine of the 51 patients experienced systemic objective tumor responses (3 complete response, 6 partial response), but had Mx concentrations in their mononuclear cells equal to the Mx levels of non-responders during IFN-α therapy. Therefore, the level of Mx-homologous protein induced during IFN therapy is not a predictive marker for an antitumor response in malignant melanoma.
- Subjects
PROTEINS; MELANOMA; THERAPEUTICS; CANCER; ANTINEOPLASTIC agents; IMMUNOGLOBULINS
- Publication
Journal of Investigative Dermatology, 1990, Vol 95, p238S
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12875854