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- Title
Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease.
- Authors
Carrasquillo, Minerva M.; Fanggeng Zou; Pankratz, V. Shane; Wilcox, Samantha L.; Li Ma; Walker, Louise P.; Younkin, Samuel G.; Younkin, Curtis S.; Younkin, Linda H.; Bisceglio, Gina D.; Ertekin-Taner, Nilufer; Crook, Julia E.; Dickson, Dennis W.; Petersen, Ronald C.; Graff-Radford, Neill R.; Younkin, Steven G.
- Abstract
By analyzing late-onset Alzheimer's disease (LOAD) in a genome-wide association study (313,504 SNPs, three series, 844 cases and 1,255 controls) and evaluating the 25 SNPs with the most significant allelic association in four additional series (1,547 cases and 1,209 controls), we identified a SNP (rs5984894) on Xq21.3 in PCDH11X that is strongly associated with LOAD in individuals of European descent from the United States. Analysis of rs5984894 by multivariable logistic regression adjusted for sex gave global P values of 5.7 × 10−5 in stage 1, 4.8 × 10−6 in stage 2 and 3.9 × 10−12 in the combined data. Odds ratios were 1.75 (95% CI = 1.42–2.16) for female homozygotes (P = 2.0 × 10−7) and 1.26 (95% CI = 1.05–1.51) for female heterozygotes (P = 0.01) compared to female noncarriers. For male hemizygotes (P = 0.07) compared to male noncarriers, the odds ratio was 1.18 (95% CI = 0.99–1.41).
- Subjects
ALZHEIMER'S disease; DISEASES in older people; GENOMES; GENES; GENETIC research; MULTIVARIATE analysis
- Publication
Nature Genetics, 2009, Vol 41, Issue 2, p192
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.305