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- Title
The Phosphatase Domains of CD45 are Required for Ligand Induced T-Cell Receptor Downregulation.
- Authors
Kastrup; Lauritsen; Menné; Dietrich; Geisler
- Abstract
Down-regulation of the T-cell receptor (TCR) plays an important role in modulating T-cell responses, both during T-cell development and in mature T cells. At least two distinct pathways exist for TCR down-regulation: down-regulation following TCR ligation; and down-regulation following activation of protein kinase C (PKC). Ligand-induced TCR down-regulation is dependent on protein tyrosine kinase (PTK) activity and seems to be closely related to T-cell activation. In addition, previous studies have indicated that ligand-induced TCR down-regulation is dependent on the expression of CD45, a transmembrane protein tyrosine phosphatase. The role of the different domains of CD45 in TCR down-regulation was investigated in this study. We found that the phosphatase domains of CD45 are required for efficient ligand-induced TCR down-regulation. In contrast, the extracellular domain of CD45 is dispensable for ligand-mediated TCR down-regulation. Finally, PKC-mediated TCR down-regulation was found to be independent of both the extra-and intracellular domains of CD45.
- Subjects
RECEPTOR-ligand complexes; T cells; CELLS
- Publication
Scandinavian Journal of Immunology, 2000, Vol 51, Issue 5
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1046/j.1365-3083.2000.00716.x