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- Title
Priming of T-Cell Responses in Mice by Porins of Salmonella typhimurium.
- Authors
Gupta
- Abstract
An imbalance in signals delivered to T cells via T-cell receptor and accessory molecules can lead to anergy, apoptosis, or both. In the present study we have demonstrated that Salmonella typhimurium infection in mice leads to a progressive loss of CD4[sup +] T helper (Th) cell population, abnormal T-cell death by apoptosis and loss of accessory molecules (B7 and intracellular adhesion molecule-1) on macrophages. Quantification of interleukin-2 (IL-2), interleukin-4 (IL-4) and interferon-γ (IFN-γ) secretion revealed a Th2-type of response in lymphocytes isolated from spleen. However, preimmunization of mice with porins resulted in an increased CD4[sup +] Th cell population and accessory molecules on the surface of macrophages. Quantification of cytokines revealed a Th1-type of response. We conclude that preimmunization of mice with porins provides a microenvironment in which a well-balanced accessory molecule and cytokine network is established, which results in the prevention of cell death by apoptosis.
- Subjects
SALMONELLA typhimurium; T cells; MACROPHAGES; VACCINATION
- Publication
Scandinavian Journal of Immunology, 1998, Vol 48, Issue 2
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1046/j.1365-3083.1998.00326.x