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- Title
Cancer Prevention by Adoptive Transfer of Antigen 60-Activated Immunocompetent Cells.
- Authors
Maes, H.; Cocito, C.
- Abstract
The authors have already shown that A60, the thermostable macromolecular antigen complex of <em>Mycobacterium bovis</em> BCG, induced resistance to tumour challenge in several murine systems. In the present work, the authors provided evidence that activated macrophages played a major role, and cytolytic T lymphocytes a minor one, in both <em>in vivo</em> and <em>in vitro</em> A60-promoted cancer cell cytolysis. To identify the types of immunocompetent cells involved in this protective effect, macrophages and T lymphocytes from A60-primed mice donors were adoptively transferred to irradiated recipients prior to EMT 6 tumour challenge. In some groups, A60-primed donors were survivors of previous tumour challenges. Transfer of T lymphocytes from the spleen or lymph-nodes of A60-immunized mice induced 80-90% protection against tumour challenge. Conversely, transferred macrophages, although cytolytically active, did not induce resistance to tumour implantation. Furthermore, adoptive transfer with T lymphocytes from A60-immunized and EMT 6 challenge-surviving donors induced 100% protection. It is concluded that stimulation of T lymphocytes by A60 is the key step which leads to activation of the immunocompetent cells involved in tumour rejection.
- Subjects
CANCER prevention; T cells; LEUCOCYTES; LYMPHOCYTES; CONNECTIVE tissue cells; ANTIGEN presenting cells; KILLER cells; MACROPHAGES; PHAGOCYTES; RETICULO-endothelial system
- Publication
Scandinavian Journal of Immunology, 1996, Vol 43, Issue 3, p283
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1046/j.1365-3083.1996.d01-37.x