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- Title
Acute Phase Protein, Serum Amyloid A, Inhibits IL-1- and TNF-Induced Fever and Hypothalamic PGE<sub>2</sub> in Mice.
- Authors
Shainkin-Kestenbaum, R.; Berlyne, G.; Zimlichman, S.; Sorin, H. R.; Nyska, M.; Danon, A.
- Abstract
The effect of serum amyloid A (SAA)on fever induced by recombinant interleukin-Iβ(rTL-1β)or recombinant tumour necrosis factor D: (rTNFα) was studied in mice. Serum amyloid A is an acute phase protein whose rise in pathological events is induced by the cytokines IL-1, IL-6 and TNF, Administration of human serum amyloid A to mice inhibited fever induced by rlL-lβ or rTNFα in vivo, while the addition of human serum amyloid A to mice liypothalamic slices inhibited IL-1β- or TNFα-induced prostaglandin E; (PGE2) production in vitro. Since serum amyloid A did not affect body temperature or hypothalmic PGE2 levels when administered alone, it may represent a specific servo-mechanism for fever regulation in acute events, and it suggests, for the first time, a possible feedback relationship between serum amyloid A and the immunoregulatory cytokines.
- Subjects
INFLAMMATORY mediators; TUMOR necrosis factors; IMMUNOREGULATION; CELLULAR immunity; GROWTH factors; CYTOKINES
- Publication
Scandinavian Journal of Immunology, 1991, Vol 34, Issue 2, p179
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1991.tb01535.x