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- Title
Rebuttal of Argument that B Cell Ig is Non-signalling.
- Authors
Langman, R. E.; Cohen, M.
- Abstract
The article reports that if immunoglobulin molecule (Ig) does not transduce a signal, then it automatically falls into the category of being a sticky end antigen binding anywhere on the Ig would be equally effective. Researchers argued on structural as well as conceptual grounds that Ig had a single functional binding site, and this implies it must, at some stage, act as a transducer of antigen-driven conformational signals. Researchers recall our general argument that it makes no biological sense to treat the B-cell antigen receptor (BAr) as a passive focusing agent, the sole role of which is to permit the induction ofantibody of too low an affinity to function effectively in ridding antigen when secreted.
- Subjects
B cells; LYMPHOCYTES; ANTIGEN presenting cells; IMMUNOGLOBULINS; GLOBULINS; PLASMA cells; BLOOD proteins
- Publication
Scandinavian Journal of Immunology, 1991, Vol 33, Issue 2, p117
- ISSN
0300-9475
- Publication type
Editorial
- DOI
10.1111/j.1365-3083.1991.tb03741.x