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- Title
Signal Sequences Distinguish Class II Histocompatibility Antigen β Chains of Different Loci.
- Authors
Gustafsson, K.; Wiman, K.; Larhammar, D.; Rask, L.; Peterson, P. A.
- Abstract
The signal sequences of two HLA-DR β chains and the DR α chain were determined. In addition, the major part of a DC β-chain signal sequence was also elucidated. The data were obtained by combining amino acid sequence analyses of isolated α and β chains with nucleotide sequencing of four cDNA clones. All signal sequences comprise 25 amino acids or more. The two HLA-DR β-chain signal sequences are identical and exhibit only marginal homology to the DC β-chain signal sequence. No homology is apparent between α- and β-chain signal sequences. The differences in the signal sequences of the DR and DC β chains suggest that these sequences may be used to assign β chains to different loci of the human major histocompatibility complex.
- Subjects
HISTOCOMPATIBILITY antigens; HLA histocompatibility antigens; TRANSPLANTATION immunology; AMINO acid sequence; MAJOR histocompatibility complex; HOMOLOGY (Biology)
- Publication
Scandinavian Journal of Immunology, 1984, Vol 19, Issue 1, p91
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1984.tb00904.x