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- Title
An Examination of MHC Restriction in the Context of a Minimal Clonal Abortion Model for Self Tolerance.
- Authors
Doherty, P. C.; Bennink, J. R.
- Abstract
This article discusses about an examination of major histocompatibility complex glycoprotein (MHC) restriction in the context of a minimal clonal abortion model for self tolerance. The fact that T-cell responses to non-self (virus) are always constrained by association with MHC has general implications for the theory of immunological tolerance. The tolerance problem may no longer be seen simply as a need to distinguish between two opposites, self and non-self. The central question now concerns the nature of the distinction between self and self plus other (self+x). The physiological mechanisms underlying MHC restriction and self tolerance must be considered concurrently.
- Subjects
MAJOR histocompatibility complex; TRANSPLANTATION immunology; HLA histocompatibility antigens; ABORTION; IMMUNE response; IMMUNOLOGY
- Publication
Scandinavian Journal of Immunology, 1980, Vol 12, Issue 4, p271
- ISSN
0300-9475
- Publication type
Editorial
- DOI
10.1111/j.1365-3083.1980.tb00067.x