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- Title
Timing of Physical Activity, Apolipoprotein E ε4 Genotype, and Risk of Incident Mild Cognitive Impairment.
- Authors
Krell‐Roesch, Janina; Pink, Anna; Roberts, Rosebud O.; Stokin, Gorazd B.; Mielke, Michelle M.; Spangehl, Kathleen A.; Bartley, Mairead M.; Knopman, David S.; Christianson, Teresa J.H.; Petersen, Ronald C.; Geda, Yonas E.
- Abstract
Objectives To investigate the timing (mid- vs late life) of physical activity, apolipoprotein ( APO)E ε4, and risk of incident mild cognitive impairment ( MCI). Design Prospective cohort study. Setting Mayo Clinic Study of Aging (Olmsted County, MN). Participants Cognitively normal elderly adults (N = 1,830, median age 78, 50.2% female). Measurements Light, moderate, and vigorous physical activities in mid- and late life were assessed using a validated questionnaire. An expert consensus panel measured MCI based on published criteria. Cox proportional hazards models were used to calculate hazard ratios ( HRs) and 95% confidence intervals ( CIs) with age as a time scale after adjusting for sex, education, medical comorbidity, and depression. Results Light ( HR = 0.58, 95% CI = 0.43-0.79) and vigorous ( HR = 0.78, 95% CI = 0.63-0.97) physical activity in midlife were associated with lower risk of incident MCI. The association between moderate activity and incident MCI was not significant ( HR = 0.85, 95% CI = 0.67-1.09). In late life, light ( HR = 0.75, 95% CI = 0.58-0.97) and moderate ( HR = 0.81, 95% CI = 0.66-0.99) but not vigorous physical activity were associated with lower risk of incident MCI. A synergistic interaction was also observed between mid- and late-life activity in reducing risk of incident MCI. Furthermore, APOE ε4 carriers who did not exercise had a higher risk of incident MCI than noncarriers who reported physical activity. Conclusion Physical activity reduced the risk of incident MCI. Exercising in mid- and late life had an additive synergistic interaction in reducing the risk of MCI.
- Subjects
MINNESOTA; RISK factors of mild cognitive impairment; AGE differences; PHYSICAL activity; APOLIPOPROTEIN E; OLDER people physiology; PSYCHOLOGY; COGNITION disorder risk factors; APOLIPOPROTEINS; CONFIDENCE intervals; LONGITUDINAL method; QUESTIONNAIRES; RESEARCH funding; STATISTICAL sampling; WECHSLER Adult Intelligence Scale; WECHSLER Memory Scale; PROPORTIONAL hazards models; DATA analysis software
- Publication
Journal of the American Geriatrics Society, 2016, Vol 64, Issue 12, p2479
- ISSN
0002-8614
- Publication type
Article
- DOI
10.1111/jgs.14402