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- Title
Immunohistochemical Detection of p53 Expression in Patients with Preoperative Chemoradiation for Rectal Cancer: Association with Prognosis.
- Authors
Jung Wook Huh; Woo Yong Lee; Seok Hyung Kim; Yoon Ah Park; Yong Beom Cho; Seong Hyeon Yun; Hee Cheol Kim; Hee Chul Park; Doo Ho Choi; Joon Oh Park; Young Suk Park; Ho-Kyung Chun
- Abstract
Purpose: The expression of p53 in patients with rectal cancer who underwent pre-operative chemoradiationand and its potential prognostic significance were evaluated. Materials and Methods: p53 expression was examined using immunohistochemistry in pathologic specimens from 210 rectal cancer patients with preoperative chemoradiotherapy and radical surgery. All patients were classified into two groups according to the p53 expression: low p53 (<50% nuclear staining) and high p53 (≥50%) groups. Results: p53 expression was significantly associated with tumor location from the anal verge (p=0.036). In univariate analysis, p53 expression was not associated with disease-free survival (p=0.118) or local recurrence-free survival (p=0.089). Multivariate analysis showed that tumor distance from the anal verge (p=0.006), ypN category (p=0.011), and perineural invasion (p=0.048) were independent predictors of disease-free survival; tumor distance from the anal verge was the only independent predictor of local recurrence-free survival. When the p53 groups were subdivided according to ypTNM category, disease-free survival differed significantly in patients with ypN+ disease (p=0.027) only. Conclusion: Expression of p53 in pathologic specimens as measured by immunohistochemical methods may have a significant prognostic impact on survival in patients with ypN+ rectal cancer with preoperative chemoradiotherapy. However, it was not an independent predictor of recurrence or survival.
- Subjects
P53 antioncogene; GENE expression; ONCOLOGIC surgery; RECTAL cancer treatment; RECTAL cancer patients; RECTAL cancer; CANCER relapse; IMMUNOHISTOCHEMISTRY; PROGNOSIS
- Publication
Yonsei Medical Journal, 2015, Vol 56, Issue 1, p82
- ISSN
0513-5796
- Publication type
Article
- DOI
10.3349/ymj.2015.56.1.82