We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A multicomponent nutrient bar promotes weight loss and improves dyslipidemia and insulin resistance in the overweight/obese: chronic inflammation blunts these improvements.
- Authors
McCann, Joyce C.; Shigenaga, Mark K.; Mietus-Snyder, Michele L.; Lal, Ashutosh; Suh, Jung H.; Krauss, Ronald M.; Gildengorin, Ginny L.; Goldrich, Alisa M.; Block, Devan S.; Shenvi, Swapna V.; McHugh, Tara H.; Olson, Don A.; Ames, Bruce N.
- Abstract
This study determined if twice-daily consumption of a nutrient-dense bar intended to fill gaps in Western diets, without other dietary/lifestyle requirements, favorably shifted metabolic/anthropometric indicators of dysregulation in a healthy direction. Three 8-wk clinical trials in 43 healthy lean and overweight/obese (OW/OB) adults, who served as their own controls, were pooled for analysis. In less inflamed OW/OB [high-sensitivity C-reactive protein (hsCRP) <1.5], statistically significant decreases occurred in weight (21.1 ± 0.5 kg), waist circumference (23.1 ± 1.4 cm), diastolic blood pressure (24.1 ± 1.6 mmHg), heart rate [HR; 24.0 ± 1.7 beats per minute (bpm)],triglycerides (272 ± 38.2mg/dl), insulin resistance (homeostatic model of insulin resistance) (20.72 ± 0.3), and insulin (22.8 ± 1.3 mU/L); an increase in HDL-2b (+303 ± 116 nM) and realignment of LDL lipid subfractions toward a less atherogenic profile [decreased small LDL IIIb (244 ± 23.5 nM), LDL IIIa (299 ± 43.7nM),andincreasedlargeLDLI(+66 ± 28.0nM)]. In the more inflamed OW/OB (hsCRP >1.5), inflammation was reduced at 2 wk (- 0.66 mg/L), and HR at 8 wk (23.4 ± 1.3 bpm). The large HDL subfraction (10.5-14.5 nm) increased at 8 wk (+346 ± 126 nM). Metabolic improvements were also observed in lean participants. Thus, favorable changes in measures of cardiovascular health, insulin resistance, inflammation, and obesity were initiated within 8 wk in the OW/OB by replacing deficiencies in Western diets without requiring other dietary or lifestyle modifications; chronic inflammation blunted most improvements.
- Subjects
ENERGY bars (Food); WEIGHT loss; DYSLIPIDEMIA; INSULIN resistance; OBESITY
- Publication
FASEB Journal, 2015, Vol 29, Issue 8, p3287
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.15-271833