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- Title
Hydrogen Sulfide Scavenges the Cytotoxic Lipid Oxidation Product 4-HNE.
- Authors
Schreier, Sabine M.; Muellner, Markus K.; Steinkellner, Hannes; Hermann, Marcela; Esterbauer, Harald; Exner, Markus; Gmeiner, Bernhard M. K.; Kapiotis, Stylianos; Laggner, Hilde
- Abstract
Highly reactive α,β-unsaturated aldehydes like 4-hydroxy-2-nonenal (4-HNE), generated from oxidation of polyunsaturated fatty acids, can bind to proteins, polynucleotides and exert cytotoxicity. 4-HNE is known to react readily with thiol and amino groups on free or bound amino acids. Recently, hydrogen sulfide (H2S) has been identified as an endogenous vascular gasotransmitter and neuromodulator which can reach up to 160 μmol/l in the brain. Markedly higher 4-HNE concentrations were reported in the brain of patients suffering from Alzheimer’s disease. Assuming that the low molecular thiol H2S may react with 4-HNE, we have tested the ability of H2S to counteract the cytotoxic and protein-modifying activity of 4-HNE. The results show that H2S at physiologically relevant concentrations could effectively protect neuronal cells (SH-SY5Y) from the cytotoxic action of 4-HNE. The HNE-modification of cellular proteins was also inhibited in presence of H2S. These data suggest that H2S may be an important protective factor against carbonyl stress by inactivating/modulating the action of highly reactive α,β-unsaturated aldehydes like 4-HNE in the brain.
- Subjects
HYDROGEN sulfide; ALDEHYDES; PHYSIOLOGICAL oxidation; UNSATURATED fatty acids; AMINO group; ALZHEIMER'S disease
- Publication
Neurotoxicity Research, 2010, Vol 17, Issue 3, p249
- ISSN
1029-8428
- Publication type
Article
- DOI
10.1007/s12640-009-9099-9