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- Title
Effects of PDGF-BB and OP-1 on Mesenchymal Stem Cells in a Porous Mineral Block.
- Authors
Wada, Keisuke; Gerbaudo, Victor H.; Spector, Myron
- Abstract
The aim of this study was to evaluate the effects of an osteogenic medium supplemented with platelet-derived growth factor (PDGF) BB and osteogenic protein (OP) 1 on the proliferation and differentiation of mesenchymal stem cells (MSCs) in an anorganic bovine cancellous bone scaffold. At day 7, there was a statistically significant increase in the number of cells in the scaffolds in the group treated with the medium supplemented with both PDGF-BB and OP-1 when compared with the control groups. The highest alkaline phosphate levels, at 14 and 21 days, were recorded for the samples in medium supplemented with OP-1 alone reflecting osteogenic differentiation. The results commend OP-1, as well as PDGF-BB, for incorporation into porous mineral scaffolds for vertical ridge augmentation.
- Subjects
DNA analysis; ALKALINE phosphatase; ANALYSIS of variance; ANIMAL experimentation; BONE morphogenetic proteins; FISHER exact test; DENTAL implants; HEALTH outcome assessment; PLATELET-derived growth factor; STATISTICS; STEM cells; DATA analysis; TREATMENT effectiveness; DATA analysis software; IN vitro studies
- Publication
International Journal of Periodontics & Restorative Dentistry, 2013, Vol 33, Issue 2, pe72
- ISSN
0198-7569
- Publication type
Article
- DOI
10.11607/prd.1670