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- Title
Dynamics of inflammation parameters prior to tachyarrhythmias in critically ill patients.
- Authors
Koreny, Maria; Reinelt, Peter; Meyer, Brigitte; Delle Karth, Georg; Geppert, Alexander; Hülsmann, Martin; Priglinger, Ute; Berger, Rudolf; Heinz, Gottfried
- Abstract
BACKGROUND: The aim of this study was to assess the dynamics of inflammation parameters prior to a tachyarrhythmic event in critically ill patients. We evaluated the course of inflammation parameters over 48 hours before the occurrence of tachyarrhythmias. METHODS: Prospective observational study conducted at a cardiologic medical-postoperative tertiary intensive care unit at the Vienna university hospital. Between November 1996 and July 1999 all consecutive patients (n = 756) were screened for the occurrence of arrhythmias. Patients with sustained tachyarrhythmias (n = 119) form the basis of the report. The tachyarrhythmia episodes were related to the evolution of C-reactive protein, leukocytes and fibrinogen during the 48 hours before the arrhythmic event. RESULTS: A total of 278 tachyarrhythmia episodes was identified (wide QRS complex tachycardia, n = 168; narrow QRS complex tachycardia, n = 108; ventricular fibrillation, n = 2). The body temperature on the day of arrhythmia was 37.4 ± 1°C. Overall, there was no statistically significant change in any inflammation parameter within 48 hours prior to tachyarrhythmias (C-reactive protein: 17.4 ± 12 [-48 h], 16.2 ± 11 [-24 h], 15.2 ± 12 [0 h] mg/dl, p = 0.2). When stratifying for different levels of C-reactive protein on the day of arrhythmia, the trend was inhomogeneous. For lower strata, values were significantly decreasing towards arrhythmias; for higher strata, an increase in C-reactive protein was observed (stratum A: 8.5 ± 7.2 [-48 h], 6.6 ± 4.9 [-24 h], 4.8 ± 2.9 mg/dl [0 h], p = 0.0001; stratum B: 16.0 ± 7.1 [-48 h], 13.8 ± 6.0 [-24 h], 14.4 ± 2.6 mg/dl [0 h], p = 0.09; stratum C: 21.2 ± 7.4 [-48 h], 21.5 ± 7.5 [-24 h], 24.9 ± 3.0 mg/dl [0 h], p = 0.008; stratum D: 34.3 ± 13.4 [-48 h], 35.7 ± 9.0 [-24 h], 39.7 ± 5.5 mg/dl [0 h], p = 0.13). CONCLUSION: In this group of critically ill patients, inflammation parameters did not change significantly during the 48 hours prior to the arrhythmic event. For different levels of C-reactive protein at the time of arrhythmia, no clear dynamics of inflammatory signs were observed.
- Publication
Wiener Klinische Wochenschrift, 2005, Vol 117, Issue 9/10, p342
- ISSN
0043-5325
- Publication type
Article
- DOI
10.1007/s00508-005-0356-5