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- Title
Association between plasminogen activator inhibitor 1 gene mutation and different subgroups of recurrent miscarriage and implantation failure.
- Authors
Khosravi, Farhad; Zarei, Saeed; Ahmadvand, Negah; Akbarzadeh-Pasha, Zahra; Savadi, Elham; Zarnani, Amir-Hassan; Sadeghi, Mohammad-Reza; Jeddi-Tehrani, Mahmood
- Abstract
Purpose: To compare plasminogen activator inhibitor type1 (PAI-1) mutation rates in different groups of patients with the record of recurrent miscarriage (RM) or implantation failure (IF) with special emphasis on the number of missed pregnancies and/or implantation failures (RM ≥ 2, IF ≥ 2, RM + IF ≥ 2, RM ≥ 3, IF ≥ 3 and RM + IF ≥ 3). Method: Case-control study from PCR products and RFLP data of DNA from blood of patients who referred to the infertility clinic including 595 patients (421 RM ≥ 2, 119 IF ≥ 2 and 55 RM + IF ≥ 2) as the case groups and 100 healthy women as the control group. Results: All six different subgroups of patients showed increased frequencies of the mutant allele (4G) in comparison to the control group ( p < 0.001) suggesting a role for PAI-1 mutation in RM and IF. Conclusions: The different patient subgroups suffer similar rates of risk in developing RM and IF when compared to controls.
- Subjects
PLASMINOGEN activator inhibitors; GENETIC mutation; MISCARRIAGE; DISEASE relapse; INFERTILITY; CONTROL groups
- Publication
Journal of Assisted Reproduction & Genetics, 2014, Vol 31, Issue 1, p121
- ISSN
1058-0468
- Publication type
Article
- DOI
10.1007/s10815-013-0125-8